Tricyclic antidepressants like amitriptyline and nortriptyline are still used for depression and nerve pain, but they come with serious side effects including dry mouth, dizziness, heart risks, and cognitive decline-especially in older adults. Learn how they work, how they compare, and how to stay safe.
Tricyclic antidepressants like amitriptyline carry high anticholinergic burden, increasing risks of dementia and dangerous heart rhythms. Safer alternatives exist, and deprescribing can reverse cognitive decline.
Amoxapine (Asendin) is a powerful but rarely used antidepressant. Learn how it compares to SSRIs, SNRIs, and other alternatives-when it works, when it doesn’t, and who should consider it.